Our days on this Earth are limited. Death is coming for us all. (Except maybe Bezos who is planning to upload his mind to AWS.) It behooves us, therefore, to spend what time we have on the things that:
b) interest us
c) we are able to affect
d) we have or can attain competence in
Importance. Significance. Leverage. Competence.
Needless to say there is a large dollop of subjectivity in judging these things, not to mention a high dose of personal preference, aptitude, inclination and Dunning-Kruger effect.
Any time we’re invited to work on something, we should be instantly cautioned if that thing does not fall comfortably in the intersection of all four, however we personally choose to judge that.